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139 However, Ishteyaque et al 126 found that increased CYP2E1 levels stimulates the unfolded protein response and the upregulation of ERs-related proteins, suppresses the expression of B-cell lymphoma 2 (BCL2), and promotes HCC development via glucose-related protein 78/activating transcription factor 6 and CCAAT/enhancer-binding protein homologous protein signaling

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Notably, genes involved in the TSS pathway, cystine uptake and glutathione recycling (such as CBS, CSE, SLC7A11 and GSR) were DNA hypomethylated after DMF treatment 30 , supporting a regulatory effect of DMF on these pathways